Levomefolate Calcium Powder for Supplement Formulations

Product Overview

L-5-Methyltetrahydrofolate (Levomefolate Calcium) Powder is the bioactive, calcium salt form of folate (Vitamin B9), known for its superior absorption and utilization in the human body. Unlike folic acid, Levomefolate Calcium does not require metabolic conversion, making it ideal for individuals with MTHFR gene polymorphisms. This highly stable and pure nutritional ingredient is widely used in dietary supplements, functional foods, and prenatal nutrition products to support cardiovascular health, homocysteine regulation, and maternal wellness.Plant Extracts 

Standardized Extracts 

Herbal Extracts 

Content Note: Prepared by our technical team based on current scientific literature. Health claims comply with FDA/EFSA guidelines. Last reviewed: May 2026

Key Ingredients & Specifications

The product is standardized for active L-5-methyltetrahydrofolate content and purity, supplied as crystalline or micronized powder suitable for multiple formulation types.

Differentiation Content

Levomefolate Calcium is the naturally active form of folate, providing superior stability, solubility, and bioavailability compared with folic acid. Micronized forms improve water solubility, allowing seamless incorporation into powders, functional drinks, and capsule formulations.

Formulation recommendations:

• L-5-Methyltetrahydrofolate 400–800 µg + Vitamin B12 2–5 µg: Prenatal Supplements
• L-5-Methyltetrahydrofolate 200 µg + Multivitamin Blend: Daily Health Capsules
• L-5-Methyltetrahydrofolate 400 µg + Omega-3 250 mg: Cardiovascular Support Powders

Applications & Benefits

L-5-Methyltetrahydrofolate Calcium Powder is used in:

• Dietary Supplements: Capsules, Tablets, Softgels
• Functional Foods & Beverages: Powders, Drinks, Fortified Foods
• Prenatal & Maternal Nutrition Products

Key benefits include:

• Supports homocysteine metabolism and cardiovascular health
• Bioactive form of folate suitable for individuals with MTHFR gene variations
• Supports prenatal nutrition and healthy fetal development

According to a study in Journal of Nutritional Biochemistry (2020), L-5-Methyltetrahydrofolate was more effective than folic acid at raising serum folate levels in subjects with MTHFR polymorphisms.

Another study in Clinical Nutrition (2019) demonstrated that Levomefolate Calcium supplementation improved homocysteine regulation, supporting cardiovascular health.

Why Choose Us – Quality, Certifications & OEM Capability

We offer high-quality Levomefolate Calcium Powder for a range of B2B applications:

• Certifications: ISO 9001, HACCP, GMP, Kosher, Halal
• Available forms: Crystalline Powder, Micronized Powder
• MOQ: 1–5 kg, depending on grade and packaging
• Private label, custom formulation, and bulk supply options
• FDA/EFSA compliant for dietary supplement and functional food use

Frequently Asked Questions

What is the typical dosage in supplements?

Dosages typically range from 200 µg to 800 µg per serving, depending on product purpose.

Is it safe for pregnancy?

Studies suggest it is safe and recommended for supporting maternal health and fetal development.

How does it differ from folic acid?

Levomefolate Calcium is the bioactive form and does not require metabolic conversion, unlike folic acid. This improves absorption and efficacy, especially for people with MTHFR gene variations.

Can it be used in functional beverages?

Yes, the micronized form is water-soluble and suitable for powders, shakes, and drinks.

Do you offer OEM and private label services?

Yes, we provide complete OEM manufacturing including formulation, packaging, and labeling for dietary supplements and functional foods.