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$1250
1-19 Others
$1100
20-199 Others
$950
≥200 Others
Product Attributes
Model No.: KS-20260301
Product Description
L-5-Methyltetrahydrofolate (commonly known as Calcium L-5-MTHF) is the biologically active form of folate, essential for supporting cellular function and homocysteine metabolism. It is widely used in dietary supplements, functional foods, and prenatal nutrition formulations. Global demand for high-purity L-5-Methyltetrahydrofolate continues to grow as manufacturers focus on advanced Nutritional Ingredients for health-conscious consumers.
Nutritional Ingredients
Content Note: Prepared by our technical team based on current scientific literature. Health claims comply with FDA/EFSA guidelines. Last reviewed: May 2026
Our L-5-Methyltetrahydrofolate is supplied as a standardized, high-purity powder suitable for various B2B applications. Key specifications include:
| Specification | Standard / Range | Test Method | Available Form |
|---|---|---|---|
| Purity (L-5-MTHF) | ≥98% | HPLC Analysis | Powder |
| Appearance | White to off-white powder | Visual Inspection | Powder |
| Moisture | <3% | Loss on Drying | Powder |
| Heavy Metals | ≤10 ppm | ICP-MS | All Forms |
| Solvent Residue | Compliant with USP | GC Analysis | All Forms |
L-5-Methyltetrahydrofolate provides superior bioavailability compared to folic acid. It is more readily absorbed and utilized by the body, reducing the need for enzymatic conversion, and is suitable for sensitive populations, including pregnant women and individuals with MTHFR gene variations.
| Form | Bioavailability | Application Advantage |
|---|---|---|
| Calcium L-5-MTHF Powder | High | Immediate utilization, supports homocysteine metabolism |
| Folic Acid | Moderate | Requires enzymatic conversion, less suitable for MTHFR variations |
| Dosage Form | Recommended Use | Target Industry |
|---|---|---|
| Capsules / Tablets | 100–400 mcg per serving | Dietary Supplements, Prenatal Nutrition |
| Powder Blends | Fortification in food & beverages | Functional Foods, Beverages |
| Softgels | 100–200 mcg per softgel | Premium Nutritional Supplements |
L-5-Methyltetrahydrofolate is used to support cardiovascular health, cellular function, and prenatal development. Key applications include:
According to a study in Nutrients (2020), L-5-Methyltetrahydrofolate demonstrated improved bioavailability and homocysteine-lowering potential compared to folic acid.
According to a study in Journal of Nutrition (2019), L-5-MTHF supplementation supported folate status in individuals with MTHFR gene variants.
We provide high-quality L-5-Methyltetrahydrofolate with full global certifications and flexible OEM services:
Studies suggest 100–400 mcg per day, depending on application and consumer group.
L-5-MTHF is the active form of folate, with higher bioavailability and immediate utilization without enzymatic conversion.
Yes, it can be incorporated into powders, beverages, bars, and other fortified foods.
Yes, it is commonly used in prenatal formulations to support fetal development and maternal folate status.
Yes, we offer OEM services for private label products, including softgels, tablets, capsules, and fortified powders with tailored dosages.

Packaging & Delivery
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